Promethazine

[Photoaggravated eczema due to promethazine cream].

Promethazine affects autonomic cardiovascular mechanisms minimally.

Promethazine hydrochloride, Phenergan, is a phenothiazine derivative with antihistaminic (H1), sedative, antiemetic, anticholinergic, and antimotion sickness properties. These properties have made promethazine a candidate for use in environments such as microgravity, which provoke emesis and motion sickness. Recently, we evaluated carotid baroreceptor-cardiac reflex responses during two Space S...

Synthesis of Radical Cation of Promethazine by Electrochemical Oxidation of Promethazine HCl, Free radical scavenging and Antibacterial Application

Accepted on 10 February 2014 _____________________________________________________________________________ ABSTRACT Promethazine HCl was oxidized electrochemically in presence of platinum electrodes as cathode and anode. The rate constant for the formation of the oxidized compound was calculated by first order plot. The rate of formation of oxidized compound increases with increase in concentra...

Antinociceptive Effect of Promethazine in Mice

Objective(s) The present study was undertaken to investigate the nociception activity of promethazine, a tranquillizer devoid of hypnotic activity in mice. Materials and Methods Antinociception was evaluated, using the acetic acid-induced writhing, tail flick, hot plate and formalin pain tests. Results Promethazine (4 and 6 mg/kg) and acetylsalicylic acid (100 mg/kg) produced a significant...

Synthesis and antitubercular activity of quaternized promazine and promethazine derivatives.

Quaternized chlorpromazine, triflupromazine, and promethazine derivatives were synthesized and examined as antitubercular agents against both actively growing and non-replicating Mycobacterium tuberculosis H37Rv. Impressively, several compounds inhibited non-replicating M. tuberculosis at concentrations equal to or double their MICs against the actively growing strain. All active compounds were...